🌿 SkincareDB

ALLANTOIN PABA

INCI Name ALLANTOIN PABA
CAS Number 4207-42-5
πŸ‡ͺπŸ‡Ί Banned
πŸ‡ΊπŸ‡Έ Approved
πŸ‡―πŸ‡΅ Approved
πŸ‡°πŸ‡· No Data
πŸ‡¬πŸ‡§ Banned

Commonly Found In

🧴Sunscreen✨Serum

Overview

Allantoin PABA is a combination ingredient that links the skin-soothing allantoin molecule with PABA (para-aminobenzoic acid), a UV absorber. It is banned in EU and UK cosmetics due to the PABA component's potential to cause photoallergic reactions. Rarely encountered in modern formulations.

Also known as: allantoin p-aminobenzoate, allantoin para-aminobenzoic acid

Key Benefits

The allantoin component may help soothe and condition skin, while the PABA component provides UV absorption. However, clinical evidence indicates a meaningful photoallergic sensitization risk, leading to its ban in the EU and UK.

Supporting Research

  • β€’ EU Cosmetics Regulation Annex II/167: Banned in EU cosmetics due to PABA-associated photoallergic reactions
  • β€’ Kaidbey KH & Kligman AM (1978): Documented photoallergic contact dermatitis from PABA in sunscreens

Skin Compatibility Ratings

Comedogenic Rating

0/5

Non-comedogenic; combination ingredient used at low concentrations.

Source: CIR Expert Panel; industry data

Irritancy Rating

2/5

Photoallergic reactions documented with PABA component; banned in EU/UK for this reason. Low irritancy in absence of UV exposure.

Source: Published photoallergy literature

Typical Use Concentration

Range

Not established for modern use

Optimal

Not applicable

Ingredient is banned in EU/UK. Rare in contemporary formulations worldwide.

Works Well With / Avoid

Avoid Combining

other PABA derivatives

Rarely used in modern formulations. EU/UK banned. PABA component has potential for photoallergic cross-reactions with sulfonamides and benzocaine.

Commonly Found In

Sunscreens (historical) Skin Conditioning Products (historical)

Global Regulation Summary

Overview of current status across major international markets.

🚫 2 Banned
βœ… 3 Allowed/Other

Detailed Regional Status

Region Status Max Conc. Conditions Source
πŸ‡ͺπŸ‡Ί EU Banned - - Official β†—
πŸ‡ΊπŸ‡Έ USA Allowed - - Official β†—
πŸ‡―πŸ‡΅ Japan Allowed - - Official β†—
πŸ‡°πŸ‡· Korea Unknown - - Official β†—
πŸ‡¬πŸ‡§ UK Banned - Follows EU regulations (II/167) Official β†—

🌍 Why Regulations Differ

Banned in EU (Annex II/167) and UK due to PABA's documented photoallergic potential. Japan and US permit it, though it is rarely used today as safer UV filters have replaced PABA-based compounds.

Regulation Analysis

Regional Agreement

High regulatory divergence

Banned in EU, UK but allowed in USA, Japan.

Category Comparison

There are 389 ingredients in the SKIN CONDITIONING category. 97% are banned in at least one major market.

Strictness Ranking

1.EUBanned
2.UKBanned
3.USAAllowed
4.JapanAllowed

🌿 Natural Sources

Not found in nature. A synthetic compound combining allantoin (found in comfrey plant) with PABA (para-aminobenzoic acid, a UV absorber).

🏭 How It's Made

Synthesized by reacting allantoin with PABA to create a single molecule that combines skin-soothing properties with UV protection.

πŸ’„ Uses in Cosmetics

Used in cosmetic products primarily for skin conditioning, uv absorber.

SKIN CONDITIONING UV ABSORBER

πŸ”¬ Other Applications

No significant non-cosmetic uses. Its components (allantoin and PABA) are used separately in medicine and food applications.

πŸ’‘ Fun Facts

  • β€’ This ingredient represents a 1960s-70s approach to cosmetics: combining a skin soother with a sunscreen in one molecule
  • β€’ Both the EU and UK banned it due to the PABA component, which can cause photoallergic reactions in some people
  • β€’ PABA was once the most popular sunscreen ingredient worldwide before being replaced by safer alternatives

Related Skin Concerns

Data Sources

  • β€’ EU Cosmetics Regulation 1223/2009 Annex II entry 167
  • β€’ Kaidbey KH & Kligman AM (1978) – Photoallergic contact dermatitis from PABA

Last data verification: 2026-04-16

Related Ingredients

Learn More

Frequently Asked Questions

Why is ALLANTOIN PABA banned in the EU but allowed in the US?

The EU follows a precautionary principle, banning ALLANTOIN PABA under II/167 due to potential safety concerns. The US FDA has not found sufficient evidence to prohibit its use, allowing it under different safety assessment standards. This reflects differing regulatory philosophies between the two regions.

Why is ALLANTOIN PABA banned in the EU but allowed in Japan?

The EU prohibits ALLANTOIN PABA (II/167) based on their strict safety criteria. Japan's Ministry of Health, Labour and Welfare (MHLW) has evaluated the ingredient and permits its use, potentially with different safety data or usage conditions.

What is ALLANTOIN PABA used for in cosmetics?

ALLANTOIN PABA is primarily used for skin conditioning in cosmetic products. It also serves as uv absorber. The ingredient is commonly found in moisturizers, lotions, and creams.

Which countries regulate ALLANTOIN PABA?

ALLANTOIN PABA is banned in EU, UK. The ingredient is freely allowed in JP, US.

Are there alternatives to ALLANTOIN PABA?

Due to regulatory restrictions on ALLANTOIN PABA, cosmetic manufacturers often use alternative ingredients with similar functions. For skin conditioning, alternatives may include other approved ingredients in the same category. Consult product labels for specific formulations, and look for products compliant with your region's regulations.

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Disclaimer

The information on this website is for educational and informational purposes only and is not intended as medical advice. While we strive for accuracy based on official government databases, cosmetic regulations change frequently. Always consult with a qualified professional or refer to the latest official regulatory documents for compliance. We are not responsible for any actions taken based on the information provided here.