5-Ureidohydantoin (ALLANTOIN)
Commonly Found In
Overview
ALLANTOIN is a cosmetic ingredient primarily used for SKIN CONDITIONING and SOOTHING properties. It promotes skin healing and cell regeneration while providing anti-inflammatory and moisturizing benefits.
Also known as: Allantoin, 5-Ureidohydantoin, Glyoxyldiureide, Hemocane (brand)
Key Benefits
Studies suggest that allantoin may promote cell proliferation and accelerate epidermal regeneration, which could support wound healing and skin barrier recovery. Clinical evidence indicates soothing and anti-irritant properties that may reduce inflammation and improve tolerance of active ingredient formulations.
Supporting Research
- β’ AraΓΊjo et al. (2010) β allantoin demonstrated dose-dependent proliferative effect on fibroblasts in vitro (J Clin Pharmacol)
- β’ Cosmetic Ingredient Review (CIR) Expert Panel (1987, reaffirmed 2010) β comprehensive safety assessment confirming soothing and healing properties
Skin Compatibility Ratings
Comedogenic Rating
Non-comedogenic; widely used even in acne-prone skin formulations
Source: CIR Expert Panel; cosmetic dermatology consensus
Irritancy Rating
Classified as an anti-irritant; does not cause irritation at standard cosmetic concentrations; listed as safe by FDA for skin protection at 0.1β2%
Source: CIR Expert Panel Final Report on allantoin; FDA OTC listing
Typical Use Concentration
Range
0.1β2%
Optimal
0.2β0.5%
FDA lists effective range as 0.1β2% for skin protection OTC use. Typical cosmetic use is 0.2β0.5% where soothing effects are desired.
Works Well With / Avoid
Works Well With
Versatile and broadly compatible with most cosmetic ingredients across pH 3β8. Enhances the tolerability of potentially irritating actives such as retinoids and exfoliating acids when co-formulated.
Commonly Found In
Global Regulation Summary
Overview of current status across major international markets.
Detailed Regional Status
| Region | Status | Max Conc. | Conditions | Source |
|---|---|---|---|---|
| πͺπΊ EU | Unknown | - | - | Official β |
| πΊπΈ USA | Unknown | - | - | Official β |
| π―π΅ Japan | Unknown | - | - | Official β |
| π°π· Korea | Unknown | - | - | Official β |
| π¬π§ UK | Unknown | - | - | Official β |
π Why Regulations Differ
Allantoin is uniformly well-accepted across global regulatory frameworks. The US FDA lists it as safe and effective at 0.1β2% for skin protection in OTC products. The EU permits it under general cosmetic regulations without concentration restrictions. Japan allows it as a cosmetic ingredient.
Regulation Analysis
Category Comparison
97% of SKIN CONDITIONING ingredients (378 of 389) are banned in the EU, but this one is approved.
πΏ Natural Sources
Found in comfrey plant root (Symphytum officinale) at 0.7-2.5% concentration (HPLC analysis shows 15.14-36.46 mg/g dry weight in commercial samples). Also present in urine of most mammals. Wheat germ, soybean, and other botanical sources contain trace amounts.
π How It's Made
Synthetically produced for cosmetic use via three methods: oxidation of uric acid, reaction of dichloroacetic acid and urea, or direct condensation of glyoxylic acid and urea (most common). Chemically synthesized bulk allantoin is chemically equivalent to natural allantoin. First synthesized from uric acid in 1837 by German chemists Friedrich WΓΆhler and Justus Liebig.
π Uses in Cosmetics
FDA-listed as effective and safe at 0.1-2% for skin protection. Typical use levels: 0.2-2%. Found in moisturizers, anti-acne products, sun care, toothpaste, mouthwash, shampoos, and after-sun products. Promotes wound healing, reduces inflammation, and enhances skin moisture retention.
π¬ Other Applications
Found in wound-healing ointments and creams, oral care products like toothpaste and mouthwash, and veterinary skin treatments.
π‘ Fun Facts
- β’ First discovered over 200 years ago (in 1800) by an Italian doctor and a French chemist
- β’ Named after the allantois membrane where it was originally found
- β’ Most animals can produce allantoin naturally in their bodies, but humans and apes cannot β we need to get it from food or skincare products
Related Skin Concerns
Data Sources
- β’ CIR Expert Panel Final Report on allantoin (1987, reaffirmed 2010)
- β’ FDA 21 CFR 347.10 (OTC skin protectant active ingredients)
- β’ EU CosIng database
- β’ AraΓΊjo et al., J Clin Pharmacol 2010
Last data verification: 2026-04-12
Related Ingredients
STRONTIUM CHLORIDE
ALLANTOIN PABA
Ξ±-Arbutin
ALPHA-ARBUTIN
AMMI MAJUS EXTRACT
Beta-Arbutin
ARBUTIN
Nonanedioic Acid
AZELAIC ACID
Learn More
Frequently Asked Questions
What is ALLANTOIN used for in cosmetics?
ALLANTOIN is primarily used for skin conditioning in cosmetic products. It also serves as soothing, anti-irritant. The ingredient is commonly found in moisturizers, lotions, and creams.
Which countries regulate ALLANTOIN?
ALLANTOIN is approved for cosmetic use in all major markets: , with no significant restrictions.
Where can I find official regulation information about ALLANTOIN?
Official information about ALLANTOIN regulations can be found on government websites: EU CosIng database, US FDA Cosmetics page, Japan MHLW cosmetics standards, UK Government cosmetics guidance, and Korea MFDS. Always verify regulatory status with these official sources before making formulation decisions.
Disclaimer
The information on this website is for educational and informational purposes only and is not intended as medical advice. While we strive for accuracy based on official government databases, cosmetic regulations change frequently. Always consult with a qualified professional or refer to the latest official regulatory documents for compliance. We are not responsible for any actions taken based on the information provided here.