🌿 SkincareDB

BENZOPHENONE-3

INCI Name BENZOPHENONE-3
CAS Number 131-57-7
πŸ‡ͺπŸ‡Ί Approved
πŸ‡ΊπŸ‡Έ Approved
πŸ‡―πŸ‡΅ Approved
πŸ‡°πŸ‡· Restricted
πŸ‡¬πŸ‡§ Banned

Commonly Found In

🧴Sunscreen

Overview

BENZOPHENONE-3 is a cosmetic ingredient primarily used for LIGHT STABILIZER. It is commonly found in various cosmetic formulations and serves important functions in personal care products.

Also known as: Oxybenzone, Benzophenone-3, 2-Hydroxy-4-methoxybenzophenone, Eusolex 4360

Key Benefits

Oxybenzone absorbs both UVB and short-wave UVA radiation, which may help protect skin from sunburn and some UV-induced photoaging. Studies suggest it provides broad-spectrum coverage, though concerns about systemic absorption and potential endocrine activity at high doses have prompted regulatory re-evaluation in several markets.

Supporting Research

  • β€’ Scheuer & Warshaw (2006) – review of sunscreen allergens including oxybenzone (Dermatitis)

Skin Compatibility Ratings

Comedogenic Rating

0/5

Considered non-comedogenic; disperses in water-based formulas without occluding pores.

Source: CIR Expert Panel safety assessment

Irritancy Rating

1/5

Low general irritancy; however, contact allergy and photoallergy occur in approximately 1-3% of the population, making it one of the more common sunscreen allergens.

Source: SCCS/1533/14; Scheuer & Warshaw 2006 (Dermatitis)

Typical Use Concentration

Range

0.5–6%

Optimal

3–6%

EU Annex VI maximum: 6% for face/body leave-on, 0.5% for spray products. FDA OTC monograph permits up to 6% (Category III classification means more data needed). Hawaii banned it effective Jan 2021 for reef protection.

Works Well With / Avoid

Works Well With

homosalate octinoxate octocrylene

Photostable organic UV filter. The SCCS (EU Scientific Committee on Consumer Safety) assessed oxybenzone at ≀6% as safe for face/body but concerns remain about spray inhalation. Hawaii and Palau have enacted environmental bans due to coral reef toxicity.

Commonly Found In

Sunscreens SPF Moisturizers Daily UV Protection Products

Global Regulation Summary

Overview of current status across major international markets.

🚫 1 Banned
⚠️ 1 Restricted
βœ… 3 Allowed/Other

Detailed Regional Status

Region Status Max Conc. Conditions Source
πŸ‡ͺπŸ‡Ί EU Allowed - - Official β†—
πŸ‡ΊπŸ‡Έ USA Allowed - - Official β†—
πŸ‡―πŸ‡΅ Japan Allowed - - Official β†—
πŸ‡°πŸ‡· Korea Restricted 5.0% When used as UV protection Official β†—
πŸ‡¬πŸ‡§ UK Banned - Follows EU regulations (VI/4) Official β†—

🌍 Why Regulations Differ

Oxybenzone is one of the most scrutinized UV filters globally due to endocrine activity concerns at high systemic doses (demonstrated in animal studies) and coral reef toxicity. The SCCS assessed it safe at EU limits. The FDA classified it Category III in 2019. Hawaii (2021) and Palau banned it environmentally. The divergence reflects different risk frameworks: human safety vs. ecosystem impact.

Recent Regulatory Changes

  • β€’ Hawaii: Ban effective January 1, 2021 (Act 104, SB 2571)
  • β€’ Palau: Ban effective January 2020
  • β€’ FDA 2019 Proposed Rule: Category III classification

Regulation Analysis

Regional Agreement

High regulatory divergence

Banned in UK but allowed in EU, USA, Japan.

Category Comparison

There are 34 ingredients in the LIGHT STABILIZER category. 100% are banned in at least one major market.

Strictness Ranking

1.UKBanned
2.KoreaRestricted
3.EUAllowed
4.USAAllowed
5.JapanAllowed

🌿 Natural Sources

Entirely synthetic aromatic ketone belonging to the benzophenone class. No natural occurrence documented.

🏭 How It's Made

Modern synthesis involves esterification where 3-benzoylbenzoic acid reacts with phenol, forming benzophenone-3 benzyl ester. Subsequent hydrolysis breaks the ester bond, yielding the benzophenone-3 molecule. Purification uses activated carbon decolorization to remove impurities, followed by recrystallization from water-methanol or ethanol-water mixture, with cooling from 60-70Β°C promoting crystal formation. Original 1906 synthesis by KΓΆnig and Kostanecki used condensation of resorcinol derivatives with benzoyl chloride.

πŸ’„ Uses in Cosmetics

A UV filter that protects skin from both UVB and short-wave UVA rays. Used at up to 6% in sunscreens. One of the most widely used chemical sunscreen ingredients worldwide.

LIGHT STABILIZER UV ABSORBER UV FILTER

πŸ”¬ Other Applications

Used to protect plastics, paints, and textiles from UV damage and fading. Also found in furniture coatings and protective varnishes.

πŸ’‘ Fun Facts

  • β€’ First created in 1906 by German chemists, but its UV-blocking ability wasn't recognized until decades later
  • β€’ Became commercially available as a sunscreen ingredient in the 1950s
  • β€’ FDA approved it for sunscreen use in the early 1980s β€” one of the first chemical UV filters approved in the US

Related Skin Concerns

Data Sources

  • β€’ EU SCCS Opinion SCCS/1533/14 on benzophenone-3
  • β€’ EU Cosmetics Regulation Annex VI
  • β€’ FDA Proposed Rule 2019 (84 FR 6204)
  • β€’ Hawaii Act 104 (2018)
  • β€’ CIR Expert Panel review

Last data verification: 2026-04-16

Related Ingredients

Learn More

Frequently Asked Questions

What is BENZOPHENONE-3 used for in cosmetics?

BENZOPHENONE-3 is primarily used for light stabilizer in cosmetic products. It also serves as uv absorber, uv filter. The ingredient is commonly found in various cosmetic and personal care products.

Which countries regulate BENZOPHENONE-3?

BENZOPHENONE-3 is banned in UK. It has concentration limits or usage restrictions in KR. The ingredient is freely allowed in EU, JP, US.

Are there alternatives to BENZOPHENONE-3?

Due to regulatory restrictions on BENZOPHENONE-3, cosmetic manufacturers often use alternative ingredients with similar functions. For light stabilizer, alternatives may include other approved ingredients in the same category. Consult product labels for specific formulations, and look for products compliant with your region's regulations.

Where can I find official regulation information about BENZOPHENONE-3?

Official information about BENZOPHENONE-3 regulations can be found on government websites: EU CosIng database, US FDA Cosmetics page, Japan MHLW cosmetics standards, UK Government cosmetics guidance, and Korea MFDS. Always verify regulatory status with these official sources before making formulation decisions.

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Disclaimer

The information on this website is for educational and informational purposes only and is not intended as medical advice. While we strive for accuracy based on official government databases, cosmetic regulations change frequently. Always consult with a qualified professional or refer to the latest official regulatory documents for compliance. We are not responsible for any actions taken based on the information provided here.